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The ReThinkHPVaccination Project was launched to improve HPV vaccination rates across EU Member States and enlargement countries by addressing misinformation, enhancing communication strategies, and implementing targeted training programs. The project aimed to support national and regional health authorities in restarting and strengthening HPV vaccination campaigns, contributing to the goals of Europe’s Beating Cancer Plan. Through extensive dissemination efforts, policy engagement, and training initiatives, the project exceeded many of its initial targets. This evaluation assesses the project’s implementation, impact, challenges, and key lessons learned to provide recommendations for future HPV vaccination advocacy and education initiatives.